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Preheat oven to 400 degrees. Place brussels sprouts on a large baking sheet and drizzle with olive oil. Sprinkle with salt and pepper. Place in oven and bake for 15 minutes.
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While sprouts are cooking place diced bacon in small skillet and cook over medium heat until crisp. Remove to paper towel lined plate.
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Whisk together horseradish, honey and mustard in small saucepan. Heat over medium heat for 5-7 minutes until thoroughly heated.
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Remove brussels sprouts from oven and place in large bowl. Toss sprouts with bacon and the glaze. Serve immediately.